Dr. med. Deniz Akdis

Mitgliedschaften

• Schweizerische Gesellschaft für Kardiologie (SGK)
• Europäische Gesellschaft für Kardiologie (ESC)
• Europäische Gesellschaft für Herzrhyhtmusstörungen (EHRA)
• Verband Schweizerischer Assistenz - und Oberärzt*innen (VSAO)

 

Aktuelle Lehrtätigkeit

• Leitung klinischer Untersuchungskurse in Innerer Medizin für Studierende der Medizin der Universität Zürich (3. und 6. Studienjahr)
• Betreuung von Masterstudentinnen und -Studenten sowie Doktorandinnen und Doktoranden der Medizinischen Fakultät der Universität Zürich

 

Experten- und Forschungstätigkeit

• Aktive Forschung im Bereich ARVC und CRT, Arbeitsgruppen Prof. Dr. Firat Duru (USZ) und PD Dr. Dr. Stephan Winnik (GZO, USZ)
• Gutachterin für diverse Fachzeitschriften, unter anderem: European Heart Journal, Journal of the American College of Cardiology

 

Preise und Auszeichnungen

• 2020: Research Grant der Schweizerischen Herzstiftung: Beurteilung der Funktion der Vorhöfe mittels Speckle-Tracking- Echokardiographie
• 2018: Research Grant der Schweizerischen Herzstiftung: Identifikation einer Proteomics Signatur bei arrhythmogener rechtsventrikulärer Kardiomyopathie
• 2017: Young Investigator Award Basic Science, Cardiostim-EHRA/Europace, Wien, Österreich
• 2017: Best Abstract Award Arrhythmia, Electrophysiology SGK 2017, Baden, Schweiz
• 2017: Poster Preis Cardiology Update Kongress 2017, Davos, Schweiz
• 2016: Best Research Presentation EHRA Young EP, Cardiostim-EHRA Europace, Nizza, Frankreich
• 2016: Filling the Gap Grant 2016 - 2017, Universität Zürich, Schweiz
• 2015: Poster Preis Cardiology Update Kongress 2014, Davos, Schweiz
• 2008: Preisträgerin 42. Nationaler Wettberwerb Schweizer Jugend Forscht mit der Arbeit: Development of a Method to demonstrate allergen-specific B-Cells

 

Ausserdem

• Sprachen: Deutsch, Türkisch, Englisch, Italienisch
• Interessen: Musik, Kunst, Theater, Ski- und Wassersport

 

Publikationen

Challenges and Pitfalls during CRT Implantation in Patients with Persistent Left Superior Vena Cava. Akdis D, Vogler J, Sieren M, Molitor N, Sasse, T, Phan HL, Bartoli L, Grosse N, Saguner A, Eriksson U, Duru F, Hofer D, Breitenstein A, Tilz R, Winnik S. Journal of Interventional Cardiac Electrophysiology. Jan 2024 (accepted)

 

Electroanatomical voltage mapping with contact force sensing for diagnosis of arrhythmogenic right ventricular cardiomyopathy. Saguner AM, Lunk D, Mohsen M, Knecht S, Akdis D, Costa S, Gasperetti A, Duru F, Rossi VA, Brunckhorst CB. Int J Cardiol. 2023 Dec 1;392:131289. doi: 10.1016/j.ijcard.2023.131289. Epub 2023 Aug 22

 

Transseptal Puncture Guided by Three-Dimensional Electroanatomical Mapping: Early Experience Using a Simplified Approach in Adults with Congenital Heart Disease. Guan F, Gass M, Berger F, Akdis D, Duru F, Wolber T. J Clin Med. 2023 Jul 5;12(13):4491. doi: 10.3390/jcm12134491

 

Evolution and triggers of defibrillator shocks in patients with arrhythmogenic right ventricular cardiomyopathy. Molitor N, Hofer D, Çimen T, Gasperetti A, Akdis D, Costa S, Jenni R, Breitenstein A, Wolber T, Winnik S, Fokstuen S, Fu G, Medeiros-Domingo A, Ruschitzka F, Brunckhorst C, Duru F, Saguner AM. Heart. 2023 Jul 12;109(15):1146-1152. doi: 10.1136/heartjnl-2022-321739

 

A Novel Heterozygous Desmoplakin Variant Causes Cardiocutaneous Syndrome with Arrhythmogenic Cardiomyopathy and Palmoplantar Keratosis. Çimen T, Medeiros-Domingo A, Kolios A, Akdis D, Anwer S, Tanner FC, Brunckhorst C, Duru F, Saguner AM. J Clin Med. 2023 Jan 24;12(3):913. doi: 10.3390/jcm12030913

 

Tissue Doppler echocardiography and outcome in arrhythmogenic right ventricular cardiomyopathy. Hosseini S, Erhart L, Anwer S, Heiniger PS, Winkler NE, Cimen T, Kuzo N, Hess R, Akdis D, Costa S, Gasperetti A, Brunckhorst C, Duru F, Saguner AM, Tanner FC.Int J Cardiol. 2022 Dec 1;368:86-93. doi: 10.1016/j.ijcard.2022.08.024. Epub 2022 Aug 12. PMID: 35970442

 

Novel Risk Prediction Model to Determine Adverse Heart Failure Outcomes in Arrhythmogenic Right Ventricular Cardiomyopathy. Chen S, Chen L, Saguner AM, Chen K, Akdis D, Gasperetti A, Brunckhorst C, Tang H, Guo G, Rao M, Li X, Song J, Duru F, Hu S. J Am Heart Assoc. 2022 Jul 5;11(13):e024634. doi: 10.1161/JAHA.121.024634. Epub 2022 Jun 29. PMID: 35766284

 

Right atrial strain and cardiovascular outcome in arrhythmogenic right ventricular cardiomyopathy. Anwer S, Guastafierro F, Erhart L, Costa S, Akdis D, Schuermann M, Hosseini S, Winkler NE, Kuzo N, Gasperetti A, Brunckhorst C, Duru F, Saguner AM, Tanner FC. Eur Heart J Cardiovasc Imaging. 2022 Jun 21;23(7):970-978. doi: 10.1093/ehjci/jeac070. PMID: 35511038

 

Changes in Exercise Capacity and Ventricular Function in Arrhythmogenic Right Ventricular Cardiomyopathy: The Impact of Sports Restriction during Follow-Up. Costa S, Koch K, Gasperetti A, Akdis D, Brunckhorst C, Fu G, Tanner FC, Ruschitzka F, Duru F, Saguner AM. J Clin Med. 2022 Feb 22;11(5):1150. doi: 10.3390/jcm11051150. PMID: 35268241

 

Novel plasma biomarkers predicting biventricular involvement in arrhythmogenic right ventricular cardiomyopathy. Akdis D, Chen L, Saguner AM, Zhang N, Gawinecka J, Saleh L, von Eckardstein A, Ren J, Matter CM, Hu Z, Chen X, Tanner FC, Manka R, Chen K, Brunckhorst C, Song J, Duru F. Am Heart J. 2022 Feb;244:66-76. doi: 10.1016/j.ahj.2021.10.187. Epub 2021 Oct 29

 

The Link Between Sex Hormones and Susceptibility to Cardiac Arrhythmias: From Molecular Basis to Clinical Implications. Costa S, Saguner AM, Gasperetti A, Akdis D et al. Front Cardiovasc Med  2021 Feb 17;8:644279. doi: 10.3389/fcvm.2021.644279. eCollection 2021

 

A Novel Diagnostic Score Integrating Atrial Dimensions to Differentiate between the Athlete’s Heart and Arrhythmogenic Right Ventricular Cardiomyopathy. Rossi VA, Niederseer D, Sokolska JM, Kovacs B, Costa S, Gasperetti A, Brunckhorst C, Akdis D, Tanner FC, Duru F, Schmied CM, Saguner AM. J Clin Med. 2021 Sep 10;10(18):4094. doi: 10.3390/jcm10184094

 

Impact of Genetic Variant Reassessment on the Diagnosis of Arrhythmogenic Right Ventricular Cardiomyopathy Based on the 2010 Task Force Criteria. Costa S, Medeiros-Domingo A, Gasperetti A, Akdis D, Berger W, James CA, Ruschitzka F, Brunckhorst CB, Duru F, Saguner AM. Circ Genom Precis Med. 2021 Feb;14(1):e003047. doi: 10.1161/CIRCGEN.120.003047. Epub 2020 Nov 24

 

Arrhythmogenic Cardiomyopathy: Clinical Determinants of Phenotype Discordance and the Impact of Endurance Sports. Costa S, Gasperetti A, Medeiros-Domingo A, Akdis D et al, J clin med. 2020. 2020 Nov 23;9(11):3781. doi: 10.3390/jcm9113781

 

Immunology of COVID-19: Mechanisms, clinical outcome, diagnostics and perspectives- A report of the European Academy of Allergy and Clinical Immunology (EAACI). Sokolowska M, Lukasik ZM, Agache I, Akdis CA, Akdis D et. al. Allergy. 2020 Oct;75(10):2445-2476. doi: 10.1111/all.14462

 

Differentiating hereditary arrhythmogenic right ventricular cardiomyopathy from cardiac sarcoidosis fulfilling 2010 ARVC Task Force Criteria. Gasperetti A, Rossi VA, Chiodini A, Casella M, Costa S, Akdis D et al. Heart Rhythm. 2021 Feb;18(2):231-238. doi: 10.1016/j.hrthm.2020.09.015. Epub 2020 Sep 22

 

Clinical predictors of left ventricular involvement in arrhythmogenic right ventricular cardiomyopathy. Akdis D, Saguner AM, Burri H, Medeiros-Domingo A, Matter CM, Ruschitzka F, Tanner FC, Brunckhorst C, Duru F. Am Heart J, 2020 May;223:34-43. doi: 10.1016/j.ahj.2020.01.019. Epub 2020 Feb 7

 

Clinical Characteristics of Patients with a Right Ventricular Thrombus in Arrhythmogenic Right Ventricular Cardiomyopathy. Akdis D, Chen Kai, Saguner AM et al. Thromb Haemost. 2019 Aug;119(8):1373-1378. doi: 10.1055/s-0039-1688829. Epub 2019 Jun 10

 

Risk score for the exclusion of arrhythmic events in arrhythmogenic right ventricular cardiomyopathy at first presentation. Vischer AS, Castelletti S, Syrris P, Bastiaenen R, Miles C, Akdis D et al. Int. J. Cardio. 2019 Sep 1;290:100-105. doi: 10.1016/j.ijcard.2019.04.090. Epub 2019 May 1

 

An autoantibody identifies arrhythmogenic right ventricular cardiomyopathy and participates in its pathogenesis. Chatterjee D, Fatah M, Akdis D, Spears DA, Koopmann TT, Mittal K, Rafiq MA, Cattanach BM, Zhao Q, Healey JS, Ackerman MJ, Bos JM, Sun Y, Maynes JT, Brunckhorst C, Medeiros-Domingo A, Duru F, Saguner AM, Hamilton RM. Eur Heart J. 2018 Nov 21;39(44):3932-3944. doi: 10.1093/eurheartj/ehy567

 

Low QRS voltage and atrial fibrillation precluding implantation of a subcutaneous implantable cardioverterdefibrillator in a patient with arrhythmogenic cardiomyopathy. Kahr P, Akdis D, Steffel J, Breitenstein A, Wolber T, Haegeli L, Brunckhorst C, Duru F, Saguner AM. Cardiogenetics 2018

 

Multiple clinical profiles of families with the short QT syndrome. Akdis D, Saguner AM, Medeiros-Domingo A, Schaller A, Balmer C, Steffel J, Brunckhorst C, Duru F. Europace. 2017 Jul 19. doi: 10.1093/europace/eux186

 

Value of a novel 16-lead high definition ECG machine to detect conduction abnormalities in structural heart disease. Li GL, Saguner AM, Akdis D, Fontaine GH. Pacing Clin Electrophysiol. 2018 Mar 30. doi: 10.1111/pace.13338

 

Intramyocardial block in patients with atrioventricular block. Li G, Saguner AM, Akdis D, Fontaine GH. J Investig Med. 2018 Mar 7. pii: jim-2017-000682. doi: 10.1136/jim-2017-000682

 

Investigation of Atrial Vortices Using a Novel Right Heart Model and Possible Implications for Atrial Thrombus Formation. Gülan U, Saguner A, Akdis D, Gotschy A, Manka R, Brunckhorst C, Holzner M, Duru F. Sci Rep. 2017 Dec 1;7(1):16772. doi: 10.1038/s41598-017-17117-3

 

Right ventricular outflow tract dimensions in arrhythmogenic right ventricular cardiomyopathy/dysplasia-a multicentre study comparing echocardiography and cardiovascular magnetic resonance. Gotschy A, Saguner AM, Niemann M, Hamada S, Akdis D, Yoon JN, Parmon EV, Delgado V, Bax JJ, Kozerke S, Brunckhorst C, Duru F, Tanner FC, Manka R. Eur Heart J Cardiovasc Imaging. 2017 May 26. doi: 10.1093/ehjci/jex092

 

Sex hormones affect outcome in arrhythmogenic right ventricular cardiomyopathy/-dysplasia: from a stem cell derived cardiomyocyte-based model to clinical biomarkers of disease outcome. Akdis D, Saguner AM, Shah K, Wei C, Medeiros-Domingo A, von Eckardstein A, Lüscher TF, Brunckhorst C, Chen HS, Duru F. Eur Heart J. 2017 Feb 18. doi: 10.1093/eurheartj/ehx011

 

Arrhythmogenic right ventricular cardiomyopathy: implications of next-generation sequencing in appropriate diagnosis. Medeiros-Domingo A, Saguner AM, Magyar I, Bahr A, Akdis D, Brunckhorst C, Duru F, Berger W. Europace. 2017 Jun 1;19(6):1063-1069. doi: 10.1093/europace/euw098

 

Update on arrhythmogenic ­cardiomyopathies. Akdis D, Brunckhorst C, Duru F, Saguner AM. Cardiovascular Medicine. 2017;20(09):195-202

 

Arrhythmogenic Cardiomyopathy: Electrical and Structural Phenotypes. Akdis D, Brunckhorst C, Duru F, Saguner AM. Arrhythm Electrophysiol Rev. 2016 Aug;5(2):90-101. doi: 10.15420/AER.2016.4.3

 

Severe Hyponatremia Leading to Complete Atrioventricular Block. Kottwitz J, Akdis D, Duru F, Heidecker B. Am J Med. 2016 Oct;129(10):e243-4. doi: 10.1016/j.amjmed.2016.05.033

 

ECG Incidental findings. Akdis D, Noce R, Brunckhorst C. Praxis (Bern 1994). 2016 Mar 2;105(5):292-5. doi: 10.1024/1661-8157/a002277

 

Arrhythmogene rechtsventrikuläre Kardiomyopathie / Dysplasie: Pathogenese, Diagnose und Therapie. Akdis D, Duru F. Ther Umsch. 2016;73(12):745-751. doi: 10.1024/0040-5930/a000859. Review. German

 

Successful epicardial ablation of ventricular tachycardia in a patient with arrhythmogenic right ventricular cardiomyopathy. Akdis D, Saguner AM, Brunckhorst CB, Duru F, Haegeli LM. Int J Cardiol. 2016 May 15;211:22-4. doi: 10.1016/j.ijcard.2016.02.119. Epub 2016 Feb 24

 

Myocardial expression profiles of candidate molecules in patients with arrhythmogenic right ventricular cardiomyopathy/dysplasia compared to those with dilated cardiomyopathy and healthy controls. Akdis D, Medeiros-Domingo A, Gaertner-Rommel A, Kast JI, Enseleit F, Bode P, Klingel K, Kandolf R, Renois F, Andreoletti L, Akdis CA, Milting H, Lüscher TF, Brunckhorst C, Saguner AM, Duru F. Heart Rhythm. 2016 Mar;13(3):731-41

 

Kardiale Synkopen und deren Behandlung; Akdis D, Duru F. Der Informierte Arzt. 2015 Mar.

 

Electrocardiographic Features of Disease Progression in Arrhythmogenic Right Ventricular Cardiomyopathy/Dysplasia. Saguner AM, Ganahl S, Kraus A, Baldinger SH, Akdis D, Saguner AR, Wolber T, Haegeli LM, Steffel J, Krasniqi N, Lüscher TF, Tanner FC, Brunckhorst C, Duru F. BMC Cardiovasc Disord. 2015 Jan 19;15(1):4

 

IgG4 production is confined to human IL-10-producing regulatory B cells that suppress antigen-specific immune responses. van de Veen W, Stanic B, Yaman G, Wawrzyniak M, Söllner S, Akdis D, Rückert B, Akdis CA, Akdis M. J Allergy Clin Immunol. 2013 Apr;131(4):1204-12. doi: 10.1016/j.jaci.2013.01.014

 

The broad spectrum of interepithelial junctions in skin and lung. Kast JI, Wanke K, Soyka MB, Wawrzyniak P, Akdis D, Kingo K, Rebane A, Akdis CA. J Allergy Clin Immunol. 2012 Aug;130(2):544-7.e4. doi: 10.1016/j.jaci.2012.04.044